Рак поджелудочной железы – Израильская онкологическая больница ЛИСОД в Киеве — Онкология, рак: лечение, диагностика и профилактика. Oncological clinic of the third millennium with a complete closed cycle. Оборудование последнего поколения, западные специалисты.

PANCREAS CANCER

Современная таргентная (целевая) терапия – это воздействие непосредственно на опухолевую клетку. Последние достижения ученых в области онкологии связаны с использованием генных технологий.

Проводя эксперименты на животных, ученые обнаружили способность ослабленных бактерий, инфицирующих поджелудочную железу, доставлять в опухоль радиоизотоп. Это оказывало губительное воздействие на опухоль.

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Поджелудочная железа по своей сути является уникальным многофункциональным органом. Она одновременно выступает в роли единственной железы организма человека, в которой выполняются экзокринная и эндокринная функция.

Карцинома поджелудочной железы – злокачественная опухоль, которая развивается из экзокринных клеток поджелудочной железы. У мужчин рак поджелудочной железы встречается чаще и занимает в структуре общей онкологической заболеваемости девятое место, у женщин – десятое. Соотношение составляет (1,3-1,5) : 1. Рак поджелудочной железы обнаруживают реже, чем другие онкологические болезни органов системы пищеварения, но он отличается большей агрессивностью. Поэтому при любых подозрительных симптомах необходимо срочно пройти обследование.
Специалисты ЛICОД обладают соответствующими знаниями и имеют большой опыт лечения этого вида рака.

Diagnostics

Только 20% карциномы поджелудочной железы диагностируют, когда опухоль ограничена лишь самой поджелудочной железой. Одним из первичных обследований является спиральная компьютерная томография с двойным контрастированием. Для подтверждения и/или уточнения диагноза проводят пункционную биопсию под контролем компьютерной томографии или УЗИ.

Современный метод исследования PET-CT применяют для определения стадии заболевания у пациентов с потенциально операбельным раком поджелудочной железы. Кроме того, ПЭТ-КТ назначают для выявления возможного рецидива болезни.

Также для диагностики используются:

• трансабдоминальная ультрасонография (ультразвуковое исследование);
• эндоскопическая ретроградная панкреатикохолангиография (ЭРПХГ);
• эндоскопический ультразвук с проведением аспирационной биопсии.

В LISOD при необходимости выполняют диагностическую лапароскопию. Лапароскопия – малоинвазивный метод вмешательства, позволяющий установить степень распространения болезни и определить необходимость хирургического вмешательства.

Treatment

Full information on the diagnosis and treatment of this type of cancer will be provided by the Lisod information service consultants:

• 0-800-500-110 (free for calls from stationary phones in Ukraine)
• or +38 044 520 94 00 – Daily from 08:00 to 20:00.

The only method that reliably increases survival is surgical treatment of carcinoma: resection of the pancreas with a tumor (pancreatododenal resection) and subsequent chemotherapy.
Other medical approaches are to facilitate individual symptoms.

Pain syndrome:

• the use of painkillers;
• radiotherapy;
• chemotherapy.

Jaundice:

• Endoscopic stenting;
• Operational treatment, which consists in the imposition of bypass anastomosis.

Obstruction of duodenum (occurs about 5% of patients):

• Operational treatment – the imposition of anastomosis between the stomach and the current intestine;
• Endoscopic stenting.

In Lisod, the entire complex of diagnostic measures and therapeutic procedures is carried out, which makes it possible to most effectively treat patients with KPJ, as well as provide palliative care.

Symptoms

Radiation therapist. Clinical oncologist. Israel

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At an early stage, the pancreatic cancer symptoms exhibits similar with the signs of other diseases. Among them: constipation – 13%, weakness – 23%, general malaise and bloating – 31%. Diabetes development often masks this disease. Sometimes a person is suspected of a gastric ulcer or gallbladder disease. More specific symptoms of pancreatic cancer are distinguished depending on the tumor site in the pancreas.

The main symptoms of pancreatic cancer are pain and jaundice. They are celebrated in 90% of patients. Jaundice is a sign of the damage to the pancreas of a malignant tumor. As a rule, jaundice accompany the lightweight, dark urine, itching.

Pain – The most painful symptom of the KPJ. The pain can be localized in the back or at the top of the left abdominal quadrant.

The third symptom of the pancreatic cancer is weight loss with a normal appetite. Most likely, this is due to the steamer – fat feces. Calipate together an increased amount of fatty acids and neutral fat is distinguished due to the fact that the outer-generating function of the pancreas is disturbed.

Vomiting and nausea, the absence of appetite is observed almost in half cases of pancreatic cancer. This is due to the squeezing of the stomach and duodenum.

Surgery is the main method of treating the disease. Pancreatic cancer chemotherapy helps to substantially reduce pain.

Laboratory research methods

Biochemical blood test and research of oncomarcres are needed. The most significant oncomarkers is CA-19-9.

Risk factors

• 30% of the cases of pancreas carcinoma (KPZ) are associated with smoking. It has been proven that smoking doubles the risk of developing KPI.
• Alcohol abuse, an insufficient amount of fresh fruits and vegetables are also essential risk factors – 20% of cases.
• 2 times increases the risk of patients with diabetes mellitus.
• Heredity is 5-10% of all CCS cases. The disease is more often associated with such hereditary states as adenomatous polyposis, unpassed colorectal cancer, hippel-Lindau syndromes, Gardner.
• Chronic pancreatitis in 5% of cases leads to pancreatic cancer.

Questions and answers

The section publishes questions of patients and answers from our specialists. Every person's question concerns a specific problem related to its illness. Patients are responsible Israeli clinical oncologists and chief physician Lisod, D.N., Professor Alla Vinnitskaya.

Specialist answers are based on the knowledge of the principles of evidence-based medicine and professional experience. Answers comply with exceptionally provided information, have a surrender and are not a medical recommendation.

The main purpose of the section – give information to the patient and his family to make a decision on the form of treatment together with your doctor. The treatment tactics proposed for you may differ from the principles set forth in the answers of our specialists. Feel free to ask your doctor about the reasons for the differences. You must be sure that you get the right treatment.

Good afternoon. The trouble came to the family – – the father is sick with cancer. Pancreatic cancer 4 st with metastases. I lay down in the hospital for 6 days, did an anesthetic and three days ago sent home, die. What should we do? Is there a chance? Dad, then worse, then better. Lies not getting up, it says poorly, good appetite, it can be turned over on the side, and then on the back. What to do? And there is no chance that doctors say? P.S. Cancer was diagnosed in May of this year, at 2 stages, but they said nothing to anyone. Thanks in advance for the answer

Hello. Unfortunately, in such a state, special treatment (chemotherapy) is not conducted. The patient shows symptomatic therapy in the conditions of the hospice / separation of palliative care, or at the place of residence.

Good afternoon. My dad is 54 years old. He has a seal of the head of the pancreas. How to treat? And whether the operation is done?

First, you should establish an accurate diagnosis. This is a tumor process or not (perform basic "tumor" markers, if suspected a tumor – biopsy, and if the markers are extremely high, then you can do without it in a transitional case). If the diagnosis of malignant tumor is established, stood is carried out (refinement of the dissemination of the process) and solving the issue of operation. If the tumor is conditionally transmitted – preoperative chemo-radiation therapy is carried out and then the possibility of the operation is again weighed. The only curable treatment method (capable of cured patient) in the event of cancer of the pancreatic head is operational intervention (pancreatododenal resection).

My mom is 71 years old. 07/10/2012Completed exposive laparotomy. Diagnosis: T4NXM1 pancreatic body cancer (peritone) 4st. 4kl. Group. Histology: fibrous tissue with adenocarcinoma metastasis. According to the surgeon, the tumor sprout into the hepatic and left gastric artery. What do you advise?

Unfortunately, there is no effective chemotherapy in this pathology. With a satisfactory overall state of your mom, you can try hemcitabine monochimotherapy.